Tylenol Overdose (NAC Dosing) Calculator
Health & FitnessEstimate N-acetylcysteine (NAC) antidote dosing for acetaminophen overdose, and check a blood level against the Rumack-Matthew treatment line. This is a reference tool for clinicians and must never be used to self-manage a real overdose.
First NAC Dose
The IV protocols weight capped at 110 kg; the oral loading dose is not capped.
Second NAC Dose
4,900
IV: the second infusion dose. Oral: the standard maintenance dose, repeated per protocol.
Third NAC Dose
4,900
IV: the third infusion dose. Oral: the maintenance dose is repeated every 4 hours through the 72-hour protocol.
Nomogram Treatment Line
150
The Rumack-Matthew treatment-line concentration at this time point. Only valid 4 hours or more after a single acute ingestion.
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Odeh Ahwal0people find this calculator helpful
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Frequently Asked Questions
Is this a substitute for medical advice?
This tool is for clinical education only and must never be used to manage a real suspected overdose. Call Poison Control or go to an emergency department immediately for any real or suspected acetaminophen overdose.
Why is the treatment line only valid after 4 hours?
Acetaminophen absorption is still ongoing before 4 hours, so an early level cannot be reliably compared to the nomogram.
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