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Protein Concentration Calculator

Chemistry & Biology

Calculate protein concentration from an absorbance reading using the Beer-Lambert law.

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01,000,000
1/(M*cm)
1 1/(M*cm)10,000,000 1/(M*cm)
0.01 cm10 cm
g/mol
1 g/mol10,000,000 g/mol
01,000,000

Protein Concentration

2,000.00

Protein concentration in milligrams per milliliter, adjusted for dilution.

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Odeh Ahwal

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Odeh Ahwal
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Frequently Asked Questions

Where does the extinction coefficient come from?

Extinction coefficient is specific to each protein, determined by its content of light-absorbing amino acids like tryptophan and tyrosine, and is commonly looked up from a reference table or calculated from the protein own sequence.

Why measure absorbance at 280nm for protein?

Aromatic amino acids, mainly tryptophan and tyrosine, absorb light strongly around 280 nanometers, making this wavelength a standard, convenient measure of total protein content in a sample.

How does the dilution factor get applied?

If a concentrated sample was diluted before its absorbance was measured, multiplying the calculated concentration by the dilution factor converts it back to the concentration of the original, undiluted stock sample.

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