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TTKG Calculator (Transtubular Potassium Gradient)

Health & Fitness

Calculate the transtubular potassium gradient used to assess kidney handling of potassium.

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mmol/L
1 mmol/L150 mmol/L
mmol/L
1 mmol/L10 mmol/L
mOsm/kg
50 mOsm/kg1,400 mOsm/kg
mOsm/kg
250 mOsm/kg350 mOsm/kg

TTKG

5.80

Transtubular potassium gradient. Educational reference only, not a substitute for clinical judgment. Only valid when urine osmolality is at least 300 mOsm/kg and urine sodium is at least 25 mmol/L.

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Odeh Ahwal

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Odeh Ahwal
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Frequently Asked Questions

What is TTKG used for?

TTKG estimates how well the kidneys are handling potassium, helping evaluate unexplained high or low potassium levels, particularly to assess whether the adrenal-kidney axis is responding appropriately.

What TTKG value is expected with low potassium?

With serum potassium below 3.5 mmol/L, a TTKG under 3 is expected as a normal response. A TTKG above 3 in this setting suggests inappropriate renal potassium wasting.

What are the requirements for a valid TTKG result?

TTKG is only considered valid when urine osmolality is at least 300 mOsm/kg and urine sodium is at least 25 mmol/L, since the formula assumes ongoing water reabsorption in the collecting duct.

Is this calculator a substitute for medical advice?

No. This is an educational reference implementation of the standard TTKG formula, not a substitute for a physicians clinical assessment.

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